Phosphotyrosine binding domain

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August undefined, 2024

WebOct 6, 2006 · The RET receptor tyrosine kinase is important for several different biological functions during development. The recruitment at the phosphorylated Tyr1062 site in RET of a number of different … WebPhosphotyrosine-Binding (PTB) Domain In general, PTB domains play a role similar to SH2 domains ( Gustafson et al., 1995 ). Based on ligand recognition, PTB domains fall into two …

The Phosphotyrosine Binding-like Domain of Talin Activates …

WebPhosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine-dependent … WebMay 13, 2024 · Figure 1. Lipid-binding abilities of some SH2 domains may contribute to spatio-temporal coordination of tyrosine kinase signaling hub dynamics. Alternative … dundee city council log in

Integrin β cytoplasmic domain interactions with phosphotyrosine …

WebMar 29, 2024 · The PI/PTB domains differ from Src homology 2 (SH2) domains in that their binding specificity is determined by residues that lie amino terminal and not carboxy terminal to the phosphotyrosine. Recently, it has been appreciated that other cytoplasmic proteins also contain PI domains. WebNumb is a membrane-associated, phosphotyrosine binding (PTB) domain-containing protein that functions as an intrinsic determinant of cell fate during Drosophila development. We … WebThe phosphopeptide binding site is a bipartite pocket on the surface of the SH2 domain. One part of the pocket is lined by conserved basic amino acid residues and binds the … dundee city council lopr

High-throughput profiling of sequence recognition by tyrosine …

Structure and ligand recognition of the phosphotyrosine binding …

WebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide variety of signaling and cytoskeletal proteins. Indeed, talin and ICAP1-α bind to integrin β tails by means of a PTB domain–NPXY ligand interaction. To assess the generality of this … WebApr 22, 2005 · Here we show that the C2 domain of PKCδ is a phosphotyrosine binding domain. We determine its specificity by peptide library screens, its affinity by isothermal titration calorimetry, and the structural basis for phosphotyrosine binding by X-ray diffraction of its crystal structure. dundee city council human resourcesWebAll three SHC1 proteins share the same domain arrangement consisting of an N-terminal phosphotyrosine-binding(PTB) domain and a C-terminal Src-homology2(SH2) domain. Both of the domains for the three proteins can bind to tyrosine-phosphorylated proteins but they are different in their phosphopeptide-binding specificities. dundee city council marchbanks

"WebDec 7, 1995 · The PTB domain is structurally similar to pleckstrin homology domains (a β-sandwich capped by an α-helix) and binds to acidic phospholipids, suggesting a possible … " - Phosphotyrosine binding domain

Phosphotyrosine binding domain

WebSeveral other PI domains have been identified that may also have binding specificity for the NPXY motif. The terminology used at present to define these domains is unclear. The … WebNov 7, 2012 · Phosphotyrosine signaling Intracellular communication is transmitted via networks of molecules that execute information transfer using protein-mediated …

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WebPhosphotyrosine (P.Tyr) residues on activated RTKs are recognized by a phosphodependent-binding domain, the SH2 domain. The recruitment of SH2 domain proteins to autophosphorylated RTKs at the plasma membrane is essential for initiating and propagating downstream signaling. http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00462

WebNov 17, 1995 · This leads to the incorporation of MA molecules into virus cores, and subsequently into uncoated viral nucleoprotein complexes. A direct interaction between … WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine …

In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to … See more APBA1; APBA2; APBA3; APPL1; EPS8; EPS8L1; EPS8L2; EPS8L3; TENC1; TNS; TNS1; TNS3; TNS4; DOK1; DOK2; DOK3; DOK4; DOK5; DOK6; DOK7; FRS2; FRS3; IRS1; IRS2; IRS4; NOS1AP; TLN1; TLN2 See more • SH2 domains also bind phosphorylated tyrosines See more • Eukaryotic Linear Motif resource motif class LIG_PTB_Phospho_1 See more WebMar 12, 1993 · A mouse phosphotyrosine phosphatase containing two Src homology 2 (SH2) domains, Syp, was identified. Syp bound to autophosphorylated epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors through its SH2 domains and was rapidly phosphorylated on tyrosine in PDGF- and EGF-stimulated cells.

WebAug 7, 1998 · EGFR binding of Shc proteins results in their tyrosine phosphorylation and subsequent activation of the Ras and Erk pathways. Shc interaction with activated …

WebApr 10, 1998 · Numb is a phosphotyrosine-binding (PTB) domain-containing protein implicated in the control of cell fate decisions during development. A modified two-hybrid screen in yeast was used to identify ... dundee city council meetingsWebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide … dundee city council live chat dundee city council myview loginWebProteins encoding phosphotyrosine binding (PTB) domains function as adaptors or scaffolds to organize the signaling complexes involved in wide-ranging physiological processes including neural development, immunity, tissue homeostasis and cell growth. Due to structural differences, PTB domains are divided into three groups represented by ... dundee city council my learnWebWe demonstrate that the phosphotyrosine binding domain of Shc is necessary and sufficient for its association with tyrosine-phosphorylated SHIP. Through site-directed mutagenesis, we have identified two tyrosines on SHIP, Tyr-917, and Tyr-1020, as the principal contact sites for the Shc- phosphotyrosine binding domain. dundee city council nursery applicationSH2 is conserved by signalization of protein tyrosine kinase, which are binding on phosphotyrosine (pTyr). In the human proteome the class of pTyr-selective recognition domains is represented by SH2 domains. The N-terminal SH2 domains of cytoplasmic tyrosine kinase was at the beginning of evolution evolved with the occurrence of tyrosine phosphorylation. At the beginning it was supposed that, these domains serve as a substrate for their target kinase. dundee city council myview dashboardWebFeb 3, 2005 · The C2 domain of PKCdelta is a phosphotyrosine binding domain. In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a … dundee city council myview