Web1 May 2024 · The YAP/TAZ activation under low density, while confers apoptosis resistance, renders cancer cells sensitivity to ferroptosis. These findings establish YAP/TAZ and Hippo pathways as novel determinants of ferroptosis. Therefore, inducing ferroptosis may have … Web11 Jun 2024 · This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic...
Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo …
Web18 May 2024 · Therefore, dysregulation of YAP/TAZ blocking apoptosis81 provides the mechanistic underpinning of their associations with the treatment resistance, recurrence and tumor dormancy.83 In comparison, much remains elusive about the biological … Web11 Jan 2024 · Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of … bmbf tierversuche
Roles of YAP/TAZ in ferroptosis - researchgate.net
Web18 Aug 2024 · Mammalian TEAD proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. The Hippo pathway plays an essential role in controlling organ size and maintaining tissue homeostasis. Downstream from the Hippo … Web1 day ago · Current evidence suggests a crucial role for ferroptosis in this process 94,99,105,108,109; however, the exact mechanisms by which ferroptosis contributes to the emergence of adaptive cell states remains unclear. Since ferroptosis is a type of cell … Web19 Oct 2024 · overcome Sorafenib-induced ferroptosis. At the same time, YAP/TAZ sustain the protein stability, nuclear localization, and transcriptional activity of ATF4 which in turn cooperates to induce SLC7A11 expres-sion. Our study uncovers a critical role of YAP/TAZ … bmbf twitter