Thioredoxin-interacting protein是什么
WebMay 15, 2024 · Thioredoxin-interacting protein (TXNIP), also known as vitamin D 3 up-regulated protein 1 (VDUP1) 1 or thioredoxin-binding protein-2 (TBP-2) 2, is a ubiquitously expressed protein with a molecular ... WebThioredoxin (Trx) is a thermostable, 12-kDa intracellular E. coli protein that is easily overexpressed and soluble even when overexpressed up to 40% of the total cellular …
Thioredoxin-interacting protein是什么
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WebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, … Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome … See more Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN … See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. … See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more
WebNov 30, 2024 · Thioredoxin interacting protein (Txnip) is an α-arrestin protein that regulates pleiotropic biological responses. Txnip acts as a cancer suppressor and is a critical regulator of energy metabolism. To investigate molecular mechanisms involving Txnip, we searched for its protein binding partners using tandem affinity purification and proteomics ... WebMar 22, 2024 · Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein 2 (TBP-2)/vitamin D3up-regulated protein 1 (VDUP1), is an α-arrestin that can bind …
WebApr 1, 2008 · In the current issue of Diabetes, Chen et al. ( 4) provide evidence that the loss of β-cell mass in response to elevated concentrations of glucose is the results of enhanced expression of a single protein, thioredoxin-interacting protein (TXNIP). TXNIP participates in control of the redox state of a cell by interacting and inhibiting ... WebNational Center for Biotechnology Information
WebA thioredoxin interacting protein mutant with all but one cysteine changed to serine (Cys247) showed an enhanced capacity to form complexes with TRX. TRX-1 nuclear expression in the tumour invasion front of patients with gallbladder carcinoma may be a useful prognostic marker for survival.
WebDec 20, 2009 · One of the proteins we identified was thioredoxin-interacting protein (TXNIP; also called VDUP1 or TBP-2), which in conditions of oxidative stress binds NALP3 and … camrystuffWebJul 29, 2024 · Aims. Thioredoxin‐interacting protein (TXNIP) is associated with activation of oxidative stress through inhibition of thioredoxin (Trx).However, some evidences point out that TXNIP acts as a scaffolding protein in signaling complex independent of cellular redox regulation. The autophagy‐lysosomal pathway plays important roles in the clearance of … fish and chip shop sutton coldfieldWebAbstract. Thioredoxin (Trx) is an inflammation-inducible small oxidoreductase protein ubiquitously expressed in all organisms. Trx acts both intracellularly and extracellularly and is involved in a wide range of physiological cellular responses. Inside the cell, Trx alleviates oxidative stress by scavenging reactive oxygen species (ROS ... fish and chip shops wadebridgeWebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, … fish and chip shop suppliers ukWebOct 21, 2024 · Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and … fish and chip shops uttoxeterWebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction ... fish and chip shops witneyWebMar 3, 2024 · Thioredoxin-interacting protein (TXNIP) has emerged as an important factor in pancreatic beta cell biology, and tight regulation of TXNIP levels is necessary for beta cell survival. However, the ... camry or lexus